Haplotype analysis for Irish ancestry

A New S-­test for Haplotype Analysis: Concordance and Discordance

A new test of inheritance, S, is proposed, which uses information from affected as well as unaffected siblings in the fam­ ily. The siblings are analyzed in terms of similarities of haplotypes. The distribution of the proposed S­test is derived under the null hypothesis of random inheritance. Mean and variance are obtained for the distribution. The test is then applied to data sets publ...

Haplotype approach for association analysis on hypertension

We applied a gene-based haplotype approach for the genome-wide association analysis on hypertension using Genetic Analysis Workshop 18 data for unrelated individuals. Association of single-nucleotide polymorphisms and clinical outcome were first assessed and haplotypes were then constructed based on the gene information and the linkage disequilibrium plot. Extensive haplotype analysis was also ...

Statistical issues for haplotype analysis in Neuroimaging

Sequential haplotype scan methods for association analysis.

Multi-locus association analyses, including haplotype-based analyses, can sometimes provide greater power than single-locus analyses for detecting disease susceptibility loci. This potential gain, however, can be compromised by the large number of degrees of freedom caused by irrelevant markers. Exhaustive search for the optimal set of markers might be possible for a small number of markers, ye...

Hidden Markov Modelling Techniques for Haplotype Analysis

A hidden Markov model is introduced for descriptive modelling the mosaic–like structures of haplotypes, due to iterated recombinations within a population. Methods using the minimum description length principle are given for fitting such models to training data. Possible applications of the models are delineated, and some preliminary analysis results on real sets of haplotypes are reported, dem...